(H1) CHEM30016 Colour-Coded Diagrams and Formulas W7-9

Description

ORGANICS: Enolate chemistry: Regiochemistry in enolate formation (kinetic and thermodynamic control; enolate structure; aldol and related reactions, Bredt's rule • Enamines: Stork enamine reaction; thermodynamic control Organometallic chemistry • Grignard reagents and organolithiums: Formation and structure; reactions with carbon electrophiles (aldehydes and ketones, strained ethers, nitriles, carbon dioxide, 1,2- addition to a,B-unsaturated carbonyls, esters) • Organocuprates: Synthesis and structure; reactions; hard- soft acid-base principle Wittig reaction • Formation of phosphorus ylids and their reaction with aldehydes and ketones; stabilized and unstabilized ylids; stereoselectivity in the Wittig reaction • Methods for functional group transformation: Oxidation and reduction Oxidation of alkenes • (a) Hydroboration (anti-Markovnikov addition) • (b) Epoxidation: Electrophilic (peracids and dioxiranes) and nucleophilic (reaction of polar alkenes with H2O2/NaOH) • (c) Dihydroxylation: cis-Dihydroxylation (KMnO4 and OsO4) and trans-dihydroxylation • (d) Oxidative cleavage of alkenes and diols • (e) Ozonolysis Oxidation of alcohols • (a) Chromium oxidants • (b) Swern oxidation Reductions • (a) Hydride reducing agents • (b) Birch reduction As well as: Conductors, semiconductors, insulators