H1 96 PHRM30008 Drugs Discovery to Market Summary.pdf

Description

I have curated a study guide that summarises all the lecture, workshop and textbook material covered during the course following the structure of the lectures. The notes are detailed but easy to understand and I used these notes solely during exam preparations to achieve a 96. Topics covered: Drug discovery strategies GPCRs signalling Ion channels Nuclear Hormone receptors Drug targets In-vivo & in-vitro models Mechanisms and models of drug action Constitutive activity and inverse agonism Allosteric/Orthosteric modulation Pharmacokinetics Use of Stem cells in drug discovery Structure-based drug design Stem cells, organoids & gene therapy in drug discovery Therapeutic antibodies Making better therapeutic antibodies: Monoclonal antibodies & alternative scaffolds Human genetics in drug development Safety in pharmacology and drug regulation Pharmacology on a chip Clinical trials