BIOM20001 Molecular and Cellular Biomedicine BIOCHEMISTRY NOTES

Description

Comprehensive MCB notes for BIOCHEMISTRY! Topics: Amino acids and peptides - Overview of free energy - Making unfavourable reactions go - Sources of energy in a cell - Features of amino acids - Amino acids - Peptide bond - Dihedral angles - Protein folding and unfolding - Chaperones - Forces that drive protein folding - Ramachandran plot - Alpha helices - Beta sheets - Reverse turns - Hierarchy of protein structure - Domains, folds, modules Protein Function - Quaternary structure and protein structure - Protein-ligand binding - Hemoglobin - Transport of H+ and CO2 by haemoglobin - Effect of BPG on haemoglobin - Carbon monoxide poisoning Enzymes - Overview of enzymes - Importance of enzymes - Types of enzymes - Enzyme kinetics - Michaelis-menten model - Double-reciprocal plots - Comparing enzyme activity - Enzyme inhibitors - Allosteric regulation - Lipids - Fatty acids - Dietary fats and triacylglycerols - Membrane lipids - Membrane composition and properties - Integral and peripheral membrane proteins - Hydropathy plots - Membrane transport Carbohydrates - Overview of carbohydrates - Monosaccharides - Glycosidic bonds - Polysaccharides structure and function - Protein glycosylation -ABO blood group antigens - Cell recognition using carbohydrates - Glucose transporters Metabolism - Glycolysis I: Preparatory phase - Glycolysis II: Payoff phase - Gluconeogenesis - Glycogen synthesis and breakdown - Krebs cycle - Oxidative phosphorylation - Electron transport chain - ATP synthesis - Allosteric regulation of glycolysis - Tissue specificity - Glucagon signalling - Adrenaline signalling - Insulin signalling - Overview of cell signalling - GPCR signalling - RTK signalling