Buy new:
$320.23
FREE delivery 5 - 12 June. Details
Only 1 left in stock.
$$320.23 () Includes selected options. Includes initial monthly payment and selected options. Details
Price
Subtotal
$$320.23
Subtotal
Initial payment breakdown
Delivery cost, delivery date and order total (including tax) shown at checkout.
Ships from
Smaller World Future AU
Ships from
Smaller World Future AU
Returns
Eligible for change of mind returns within 30 days of receipt
Eligible for change of mind returns within 30 days of receipt
This item can be returned in its original condition within 30 days of receipt for change of mind. However, if your item is damaged or defective, you may be entitled to a remedy after 30 days. Contact the seller or visit Third-Party Seller Returns to learn more.
Read our returns policies
Returns
Eligible for change of mind returns within 30 days of receipt
This item can be returned in its original condition within 30 days of receipt for change of mind. However, if your item is damaged or defective, you may be entitled to a remedy after 30 days. Contact the seller or visit Third-Party Seller Returns to learn more.
Read our returns policies
Payment
Secure transaction
Your transaction is secure
We work hard to protect your security and privacy. Our payment security system encrypts your information during transmission. We don’t share your credit card details with third-party sellers, and we don’t sell your information to others. Learn more
Payment
Secure transaction
We work hard to protect your security and privacy. Our payment security system encrypts your information during transmission. We don’t share your credit card details with third-party sellers, and we don’t sell your information to others. Learn more
New & Used (7) from
$108.99  & FREE Delivery
Kindle app logo image

Download the free Kindle app and start reading Kindle books instantly on your smartphone, tablet or computer—no Kindle device required.

Read instantly on your browser with Kindle for Web.

Using your mobile phone camera, scan the code below and download the Kindle app.

QR code to download the Kindle App

Follow the authors

R. W. Old
Follow
S. B. Primrose
Follow
Something went wrong. Please try your request again later.

Principles of Gene Manipulation: An Introduction to Genetic Engineering Paperback – 8 December 2001

by Sandy B. Primrose (Author), Richard Twyman (Author), Bob Old (Author)
4.7 out of 5 stars 9
See all formats and editions

There is a newer edition of this item:

Principles of Gene Manipulation and Genomics
Principles of Gene Manipulation and Genomics
$97.76
(17)
Available to ship in 1-2 days
{"desktop_buybox_group_1":[{"displayPrice":"$320.23","priceAmount":320.23,"currencySymbol":"$","integerValue":"320","decimalSeparator":".","fractionalValue":"23","symbolPosition":"left","hasSpace":false,"showFractionalPartIfEmpty":true,"offerListingId":"ETdhuPDtMx1kTftFC0BEuRET2D6mg%2BPR9vpFpZbf3IMX2fuKxfnx%2FXlSDk2NzVJfsDiODdLkKOZ%2BKShvD32IAKi6IHI7vuf5mRGOKfuUpRG9%2BhtCTG9KED7yGBvy7eV7GFqHXW9FYjWgz6%2F84rkF1a%2BBfB4XfqBg7mdWt0zV1SNuFqxDHHrt3t56ueC3miE1","locale":"en-AU","buyingOptionType":"NEW","aapiBuyingOptionIndex":0}]}

Purchase options and add-ons

Now in its sixth edition, Principles of Gene Manipulation provides an excellent introduction to the area of genetic engineering of plants, animals and microbes for advanced level undergraduates, with a basic understanding of genetics. This classic textbook has been substantially updated and revised to reflect the rapid advances that have been made in the core technologies in the seven years since the last edition. Furthermore, to put these technologies into context, the final chapter has been structured into six themes:
· nucleic acids as diagnostic tools
· new drugs and new therapies for genetic diseases
· combating infectious disease
· protein engineering
· metabolic engineering
· modern plant breeding
A website is now available to complement this text, at www.blackwellpublishing.com/primrose

    • Sixth edition of an extremely popular textbook.
    • A complete rewrite by a new author team.
    • Emerging technologies replace obsolete procedures.
    • A new chapter on genomics and proteomics.
    Previous page
    1. Print length
      400 pages
    2. Language
      English
    3. Publisher
      Wiley–Blackwell
    4. Publication date
      8 December 2001
    5. Dimensions
      19.3 x 1.74 x 24.9 cm
    6. ISBN-10
      0632059540
    7. ISBN-13
      978-0632059546
    8. See all details
    Next page

    Product description

    Review

    From the fifth edition: "This book perpetuates the quality and utility which have made its previous editions probably the best introductory text on gene manipulation of the past decade and a half: a generation of our students have relied on it." Journal for the Society for General Microbiology,1995

    "The authors are to be congratulated for their courageous effort to bring the new edition up–to–date in an area that is a technological hallmark of the 21st century[...]The starting level is still well suited to advanced undergraduates, but it quickly leads to specialized sophisticated technologies and applications[...]overall, the scientific content of this book is seriously impressive, its coverage comprehensive and it will undoubtedly become an important resource to students, course organizers and young scientists" Irina R. Tsaneva MICROBIOLOGY TODAY August 2002

    "Now in its sixth edition, Principles of Gene Manipulation is obviously quite well–honed and serves the needs of its traditional target readership – advanced undergraduates or early postgraduates – extremely well. It is clear that it would be equally useful to other types of reader requiring lucid and well–balanced descriptions of what can now be done with genes." C David O′Connor, University of Southampton, Heredity, November 2003

    From the Back Cover

    Now in its sixth edition, Principles of Gene Manipulation provides an excellent introduction to the area of genetic engineering of plants, animals and microbes for advanced level undergraduates, with a basic understanding of genetics. This classic textbook has been substantially updated and revised to reflect the rapid advances that have been made in the core technologies in the seven years since the last edition. Furthermore, to put these technologies into context, the final chapter has been structured into six themes:
    · nucleic acids as diagnostic tools
    · new drugs and new therapies for genetic diseases
    · combating infectious disease
    · protein engineering
    · metabolic engineering
    · modern plant breeding
    A website is now available to complement this text, at     www.blackwellpublishing.com/primrose

    Product details

    • Publisher ‏ : ‎ Wiley–Blackwell; 6th Edition (8 December 2001)
    • Language ‏ : ‎ English
    • Paperback ‏ : ‎ 400 pages
    • ISBN-10 ‏ : ‎ 0632059540
    • ISBN-13 ‏ : ‎ 978-0632059546
    • Dimensions ‏ : ‎ 19.3 x 1.74 x 24.9 cm
    • Customer Reviews:
      4.7 out of 5 stars 9

    About the authors

    Follow authors to get new release updates, plus improved recommendations.
    Previous page
    1. R. W. Old

      R. W. Old

      Brief content visible, double tap to read full content.
      Full content visible, double tap to read brief content.

      Discover more of the author’s books, see similar authors, read author blogs, and more

      See more on the author's page
    2. S. B. Primrose

      S. B. Primrose

      Brief content visible, double tap to read full content.
      Full content visible, double tap to read brief content.

      Discover more of the author’s books, see similar authors, read author blogs, and more

      See more on the author's page
    Next page

    Customer reviews

    4.7 out of 5 stars
    4.7 out of 5
    9 global ratings

    Review this product

    Share your thoughts with other customers
    Write a customer review

    Top reviews from Australia

    There are 0 reviews and 0 ratings from Australia

    Top reviews from other countries

    John L.
    5.0 out of 5 stars Five Stars
    Reviewed in the United Kingdom on 6 July 2016
    Verified Purchase
    Thanks
    Report
    Dr. Lee D. Carlson
    5.0 out of 5 stars Excellent overview of a very exciting field
    Reviewed in the United States on 18 May 2002
    Verified Purchase
    Certainly one of the most exciting developments in the last quarter century, genetic engineering is also one of the most controversial, and discussions of it are typically accompanied by vehemence and exaggerations. An objective study of genetic engineering is thus mandatory for everyone in the 21st century. This book is one of the best treatments of genetic engineering that I have read, and I am speaking not as a biologist but as someone actively involved in bioinformatics and computational biology. The explanations of the techniques of genetic engineering are excellent and the reader with a fairly good background in biochemistry should have no problem following the presentation. Readers without such a background will find the reading a little more demanding. One can only admire the ingenuity of the many researchers and technicians who have developed these techniques. The only thing missing in the book are exercises at the end of each chapter to test the readers understanding of the relevant concepts.
    The last five chapters of the book are the most interesting ,for it is in these chapters that the authors discuss the genetic manipulation of animals, transgenic strategies, and biotechnology. We are all priveleged to be witnessing the development of new breeds of plants and animals, and hopefully this trend will continue in the 21st century. The impact of genetic engineering for medicine and agriculture will be immense, but even more mundance activities such as gardening and horticulture will be even more interesting with the development of new kinds of plants via transgenic strategies. In addition, genetic engineering is finding applications to areas outside of biology. It was recently reported that genetically engineered viruses are being used to assist in the development of quantum dots in microelectronics.
    Some of the features of the book I found particularly helpful or interesting were: 1. The numerous diagrams employed in the book that tie concepts together or give flow charts for laboratory procedures. 2. The discussion on the physics of gel electrophoresis. Apparently the dynamics of stained molecules undergoing electrophoresis is poorly understood. 3. The historical and anecdotal information that the authors include at various places in the book. 4. The discussion on optimizing translation. The degeneracy of the genetic code might lead one to believe that the choice of codons by genes is essentially a random process. The authors argue this is not the case and give excellent references for further reading on this. Apparently protein translation is a tight scheme, and again, this is surprising given the degeneracy of the genetic code. 5. The box on express sequence tags. The most interesting part of this discussion was on the legal issues involving the patenting of ESTs. The patent applications were rejected because ESTs were viewed as incomplete sequences. This rejection might serve as a precedent to future attempts to patent genes or complete genomes. Will some of these patents be rejected on the grounds that genes do not completely determine the protein(s) or phenotype(s)? Whatever the outcome, the legal profession in the 21st century will have to deal with information-theoretic criteria when addressing patent issues in genetic engineering. 6. The listing of the Internet tools available for gene sequencing and protein structure. 7. The discussion on the quantitative effect of sequence accuracy on gene accuracy, assuming the random occurence of sequencing errors. The diagram shown of average sequence-error rate versus the fraction of error-free genes shows clearly the importance of robust and precise sequence-similarity search algorithms. Interestingly, the authors argue that, in spite of the success of statistical methods in these algorithms, the use of these methods will decrease as new sequences are accumulated and sequence conservation is used as the criterion for gene identification. They do however state that these methods will still remain useful for localizing frame shifts and for the choice of the initiation codon. 8. The box on the modes of replication of circular DNA molecules. The biophysicist reader will appreciate the discussion on the two types of replication: by theta-like structures or the rolling-circle type of mechanism. 9. The discussion on applications of transgenic mice, position effects, and transgene silencing. The authors discussion of the efficacy of transgenic strategies in mice progeny is fascinating in that some mice progeny has expression that was very different from that of the parents, or even absent. The authors give a brief discussion of boundary elements and matrix attachment regions with references for further reading. 10. The short discussion on transgenic fish. 11. The box on control of transgene expression in plants. 12. The discussion on the use of immunosuppressant drugs as chemical inducers of dimerization. The side effects of these drugs has prompted research into finding transgene induction strategies that do not have these side-effects. 13. The discussion on post-translational inducible protein activity. 13. The discussion on visible marker genes, especially the discussion on green flourescent protein. 15. The discussion on the use of antisense RNA to regulate gene expression in prokaryotes. 16. The discussion on the use of cosuppression in increasing the amount of pigment synthesized by petunia flowers. The application of transgenic strategies to horticulture is indeed exciting and one that will hopefully result in new varieties of houseplants and garden fruits and vegetables. 17. The discussion on the role of functional genomics. 18. Transgenic animals and plants as bioreactors: Tracy and her progeny in producing AAT. 19. Xenotransplantation. This is no doubt one of the most controversial techniques used in genetic engineering today.
    6 people found this helpful
     Report